SERMORELIN (GRF 1-29)

Sermorelin GRF (1-29) 

Peptide Sermorelin (also often marked as GRF (1-29) or GHRH (1-29)) is an analogue of endogenous human peptide hormone Growth hormone releasing hormone (GHRH, GRF 1-44). It consists of the first 29 amino acids found in the 44-amino acid chain of GHRH. This fragment (1-29) is considered to be the shortest fully functional fragment of GHRH. Sermorelin has an amino acid sequence TYR-ALA-ASP-ALA-ILE-PHE-THR-ASN-SER-TYR-ARG-LYS-VAL-LEU-GLY-GLN-LEU-SER-ALA-ARG-LYS-LEU-LEU-GLN-ASP-ILE-MET-SER-ARG-NH2, chemical formula C₁₄₉H₂₄₆N₄₄O₄₂S and molar mass 3357.882 g/mol. 

Sermorelin Mechanism of action

Sermorelin is a mimetic of GHRH and works just like endogenous GHRH: Seremorelin binds to Growth hormone releasing hormone receptors (GHRHRs) in the pituitary. This leads to the stimulation of Growth hormone secretion from Somatotropes (somatotropic cells) in the anterior pituitary in a pulsatile fashion. The resulting effects of Sermorelin are derived from the results of natural Growth hormone activity in the body.

Sermorelin and clinical use

Sermorelin has been officially approved in 1997 by the FDA for medical use as diagnostic agent and treatment in children with growth hormone deficiency (GHD; GH deficiency). In children who cannot grow normally due to growth hormone deficiency, Sermorelin can be used to increase the amount of growth hormone produced by the pituitary gland and to treat GHD-related diseases and health problems (growth failure, dwarf, delayed puberty, etc). Since Sermorelin is approved as a safe medicine for use in children to increase growth hormone production, it is also considered safe for adults with growth hormone deficiency, and often prescribed by doctors as medicine or anti-aging therapy for adult.

Symptoms and problems associated with GH deficiency

Possible symptoms & health problems associated with Growth hormone deficiency in children:

• • The most common symptom of GHD in children is growth failure (the child is significantly shorter than other children of the same age)
  • Immature appearance, compared to peers
  • Increased fat around the face and stomach
  • A chubby body build
  • A prominent forehead
  • An underdeveloped bridge of the nose
  • Slow tooth development
  • Sluggish hair growth
  • Delayed puberty

Possible symptoms & health problems associated with Growth hormone deficiency in adults:

• • Decreased muscle mass, strength, endurance and performance
  • Fat accumulation (especially around the waist)
  • High levels of LDL (the “bad”) cholesterol
  • Reduced bone density, osteoporosis
  • Cardio-vascular problems
  • Worsening memory and brain functions
  • Difficult to concentration
  • Anxiety, depression
  • Fatigue, low energy levels
  • Decrease in sexual function
  • Baldness (in men)
  • Poor appearance of hair and nails
  • Dry skin, decrease in collagen production
  • Premature aging
  • And many other health problems..

Scientifically investigated possible benefits of Sermorelin

• • Sermorelin stimulates and increases the secretion of growth hormone by pituitary 
  • Sermorelin helps to improve overall regeneration (incl. internal organs)
  • Sermorelin helps stimulate protein synthesis, muscle maintenance and growth
  • Sermorelin helps to burn excess fat
  • Sermorelin helps to increase calcium retention in the bones
  • Serremolin may help reduce the risk of cardio-vascular diseases
  • Sermorelin supports the proper functioning of the brain and its health
  • Sermorelin promotes a sense of energy and vitality
  • Sermorelin provides anti-aging effects
  • Sermorelin supports better sleep quality

Sermorelin possible side-effects

• • Sermorelin may cause pain, redness, or swelling at the place of injection
  • Sermorelin may cause tingling sensation in the feet and hands
  • Sermorelin may cause excessive water retention
  • Sermorelin may cause headache
  • Sermorelin may cause nausea
  • Sermorelin may cause hyperactivity
  • Sermorelin may cause flushing
  • Sermorelin may cause sleepiness

Sermorelin FAQ

What is sermorelin?

Sermorelin is a truncated analog of the endogenous peptide hormone growth hormone releasing hormone (GHRH), consisting of its first 29 amino acids.

What does sermorelin do?

Sermorelin mimics the action of endogenous GHRH: it binds to receptors for growth hormone releasing hormone in the pituitary gland, this stimulates the growth hormone secretion from the somatotropes in the anterior pituitary in a pulsating manner. As a result, endogenous growth hormone production is increased.

What is sermorelin used for?

Sermorelin has been approved by the FDA for medical use as diagnostic agent and treatment in children with growth hormone deficiency (GHD). Sermorelin can be used to increase the amount of growth hormone produced by the pituitary gland in children and adults suffering from GHD and to treat GHD-related diseases and health problems.

How long does it take to see results from sermorelin?

Some symptoms and improvements may be observed relatively quickly after the first doses of sermorelin (such as improved sleep quality, improved levels of vitality and energy, or improved hair and skin appearance). However, usually all the possible benefits and full effects of sermorelin will only take effect after a few months of treatment.

What are the benefits of sermorelin use?

The possible benefits of sermorelin use may include improved overall regeneration, muscle maintenance and growth, fat burning, calcium retention in the bones and sleep quality; anti-aging effects; reduced the risk of cardio-vascular diseases or promoting brain functions.

Does sermorelin make you lose weight?

Sermorelin helps to burn excess fat and increases fat utilization by stimulating triglyceride degradation and adipocyte oxidation.

Is sermorelin better than hGH?

One of the great advantages of Sermorelin is that unlike injections of recombinant hGH (rhGH), Sermorelin does not degrade your own natural growth hormone production. Sermorelin also significantly reduces the risk of overdose and frequent possible side effects that may occur with the use of recombinant rhGH, and does not have as much negative effect on blood sugar levels as rhGH, what eliminates the risk of high blood sugar and diabetes.

Does sermorelin help you sleep?

People who started sermorelin treatment reported better sleep quality. Sleep cycles usually return to a more normal level and sleep is better and deeper.

Where do you inject sermorelin?

Sermorelin should be injected under the skin (subcutaneously) usually once a day before bedtime; or use as directed by the physician. The dose depends on your weight, health and response to treatment.

Does sermorelin make you sleepy?

Since growth hormone is mostly released during sleep, the best time to take Sermorelin is before bedtime. Also, Sermorelin promotes sleep, so taking it during the day can make you tired or sleepy.

What time of day should I take sermorelin?

The best time to take Sermorelin is prior to bedtime. Growth Hormone is primarily released during sleep and most beneficial to the body’s recovery and repair during this time. Sermorelin has a promoting effect on sleep and can therefore make you tired if taken during the day.

Is sermorelin FDA approved?

Sermorelin has been officially approved in 1997 by the FDA for medical use as diagnostic agent and treatment in children with growth hormone deficiency (GHD; GH deficiency).

What is sermorelin made of?

Sermorelin acetate (sermorelin) is the acetate salt of an amidated synthetic 29- amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues.

Can you take too much sermorelin?

Using too much will increase the risk of side effects, while using too little may not improve the condition.

Sermorelin dosage

For therapeutic use, a dose of 200-300 mcg of Sermorelin once daily before bedtime by subcutaneous injection is recommended. It is also recommended to alternate the sites of subcutaneous injection regularly.

Overview

Sermorelin is a truncated analog of the endogenous peptide hormone growth hormone releasing hormone (GHRH), consisting of its first 29 amino acids. Sermorelin mimics the action of endogenous GHRH: it binds to receptors for growth hormone releasing hormone in the pituitary gland, this stimulates the growth hormone secretion from the somatotropes in the anterior pituitary in a pulsating manner. As a result, endogenous growth hormone production is increased. Sermorelin has been approved by the FDA for medical use as diagnostic agent and treatment in children with growth hormone deficiency (GHD). Sermorelin can be used to increase the amount of growth hormone produced by the pituitary gland in children and adults suffering from GHD and to treat GHD-related diseases and health problems.