MGF (mechano growth factor, IGF-1Ec) description
The transcription of the IGF-1 (insulinlike growth factor 1) gene generates its 3 mRNA isoforms: IGF-1Ea, IGF-1Eb and IGF-1Ec (often called also as MGF or mechano growth factor). This means, IGF-1Ec is a splice variant of IGF-1, sharing an identical mature region, but with a different E domain. IGF-1Ec has been shown in vitro as well as in vivo to induce growth and hypertrophy in mechanically stimulated or damaged muscle. It is naturally occurring endogenous peptide, but it can be produced also synthetically.
Clinical trials and MGF – IGF-1Ec results
Scientific research and clinical trials have shown, that MGF (IGF-1Ec) does have neuroprotective effects, plays important roles in tissue growth, wound healing or cardiac repairs. But especially important MGF is and plays key role to muscle repair following injury, after strenuous physical work and overload.
PEG-MGF is Pegylated Mechano Growth Factor, long-acting variant of MGF, with significantly extended biological elimination half-life: Main disadvantage of MGF (IGF-1Ec) is an extremely short half-life, calculated in a few minutes only (only 5-7 minutes). Pegylation is the process of joining 1 or more strings with the aid of a substance called polyethylene glycol (PEG) molecule to the protein or peptide.
Polyethylene glycol is an inert, non-toxic and very appropriate protection of the amine group due to its structure and flexibility. Since the body does not respond to PEG, its helps to provide a protective barrier around the desired protein or peptide. This results to increase of its half-life and peptide will be able to survive in the body and act a much longer. Pegylation is often used to protect substances that are often exposed to enzymatic attacks.
Scientifically investigated possible benefits of MGF
- Strong anabolic effect and ability repair and rebuild muscles
- Ability to induce muscle hyperplasia (growth of new muscle cells)
- Neuro-protective effect (protects the nervous system and brain functions)
- Mediates myocardial cell survival and myocardium repairs
- Important roles in tissue growth and wound healing
- Positive role on bone injury healing
MGF possible side-effects
- Possible correlation insulin-like growth factor 1 to certain forms of cancer development (however, performed studies are often unclear, and often with conflicting or very different results)
IGF-1 and MGF FAQ
What is Mechano growth factor?
Mechano Growth Factor (MGF, IGF-1EC ) is a splice variant of Insulin-like Growth Factor 1 (IGF-1) peptide hormone.
What is the difference between MGF and PEG-MGF?
MGF does break down within 5-7 minutes. Due to this, scientists have found a way to isolate it and modify it, by adding a compound. Result is PEG-MGF (Pegylated Mechano Growth Factor), with significantly increases its half-life from minutes to several days.
Does IGF 1 cause water retention?
MAY: IGF-I treatment may cause fluid and sodium retention..
Why is it called Insulin Like Growth Factor?
The name insulin-like growth factor reflects the fact that these substances have insulin-like actions in some tissues, though they are far less potent than insulin in decreasing blood glucose concentrations.
Does insulin affect growth hormone?
YES: Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathway.
What IGF 1 inhibits?
The hypothalamic growth hormone (GH)-releasing hormone (GHRH) promotes non-rapid eye movement sleep (NREMS). Insulin-like growth factor-1 (IGF-1) acts as a negative feedback in the somatotropic axis inhibiting GHRH and stimulating somatostatin.
Does Testosterone increase IGF 1?
It is hypothesized that testosterone might induce the synthesis of IGF-1 which could affect cell proliferation.
What is a IGF 1 blood test?
A somatomedin C test, also called an insulin-like growth factor-1 (or IGF-1) test, helps doctors evaluate whether a person is producing a normal amount of human growth hormone (hGH, or somatotropin).
In scientific and clinical studies doses of PEG-MGF are reported as 200-300 mcg 2-3 times weekly.