IGF-1 LR3

IGF-1 LR3 description

Synthetic peptide IGF-1 LR3 is lengthened analogue of endogenous peptide hormone IGF-1 (human insulin-like growth factor 1). Unlike regular IGF-1, its prolonged version IGF-1 LR3 haves an arginine instead of a glutamic acid at the third position in its amino acid sequence (“arginine 3”), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) (“long”). Total length of its amino acid chain is 83 amino acids unlike 70 amino acids of regular IGF-1.

IGF-1 LR3 still retains its strong pharmacological activity as an agonist of the IGF-1 receptor, but due to the mentioned modifications has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs) unlike regular IGF-1 does have, and also has improved metabolic stability. As a result, it is approximately three times more potent than IGF-1, and possesses a significantly longer half-life of about 20 hours. The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.

Clinical trials and IGF-1 LR3 results

Clinical trials have shown, that IGF-1 LR3 binds with high-affinity to IGF-1 receptor (IGF1R), and due to its significantly reduced binding to IGF-binding proteins, is even more metabolic stable and potent than regular IGF-1 in stimulating hypertrophy and proliferation of cells. IGF-1 LR3 can be suitable treatment in catabolic states (using the peptide to induce anabolism in catabolic conditions such as muscular dystrophy). IGF-1 has a strong ability to maintain and build muscle. In addition to a direct anabolic effect on skeletal muscle, the production of more IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells (satellite cells) – real growth of new muscle cells. Peptide hormone IGF-1 is the only hormone that can do this. 

Scientifically investigated possible benefits of IGF-1 LR3

• • Overall regeneration of the whole body (incl. internal organs), increased cellular repair 
  • Anti-aging effects, rejuvenation and the ability to slow-down the aging
  • Increased collagen production, healthier skin, helping to smooth out wrinkles
  • Strong anabolic effect / promoting muscle growth, strength and performance
  • Ability to induce muscle hyperplasia – the growth of new muscle cells
  • Strong anti-catabolic effect / protection against muscle wasting
  • Increased bone mineral content / greater bone mineral density
  • Improved cognitive functions, improves learning and memory
  • Promotes regeneration of the nervous system and brain health
  • May reduce risk of heart & cardio-vascular diseases
  • Strengthened immune system
  • Anti-inflammatory effects
  • Improved gut health

IGF-1 LR3 possible side-effects

• • Possible correlation insulin-like growth factor 1 to certain forms of cancer development (however, performed studies are often unclear, and often with conflicting or very different results)
  • Risk for diabetes (performed studies are often unclear)
  • Low blood sugar
  • Joint pain
  • Nausea
  • Acne

IGF-1 LR3 FAQ

Is IGF 1 LR3 use legal in Sport?

NO: Use of IGF-1 products is banned by the United States Anti-Doping Agency, World Anti-Doping Agency, and most professional sports organizations. IGF-1 is also on the OPSS list of DoD-prohibited substances, so Military Service Members should avoid products with this ingredient.

Does IGF-1 LR3 build muscle?

YES: IGF-1 has a strong ability to promote muscle growth, especially DES(1-3) IGF-1 form. In addition to a direct anabolic effect on skeletal muscle, the production of more IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells (satellite cells) – real growth of new muscle cells (IGF-1 is the only hormone that can do this). Due from this properties it is very promising candidate for treat catabolic diseases such as muscular dystrophy etc.

What is a normal IGF-1 level?

One study reports the median serum IGF-I level is about 370 ng/ml at the age of 18. The European Prospective Investigation into Cancer and Nutrition (EPIC) study reported an average serum IGF-1 level of 200-210 ng/ml, suggesting that this is a typical level for adults on a Western diet. Low IGF-1 levels associated with an increased risk of disease or mortality are generally about 70-80 ng/ml or lower.

Can IGF-1 LR3 cause diabetes?

UNCLEAR: Studies showed that low and high IGF-I levels are related to impaired glucose tolerance and to a higher risk of type 2 diabetes.

Does IGF 1 cause water retention?

MAY:  IGF-I treatment may cause fluid and sodium retention.

Does organic milk have IGF 1?

YES: All milk based products, whether they’re non organic dairy products or organic milk and organic cheese, contain a certain amount of IGF-1.

Why is it called Insulin Like Growth Factor?

The name insulin-like growth factor reflects the fact that these substances have insulin-like actions in some tissues, though they are far less potent than insulin in decreasing blood glucose concentrations.

Does insulin affect growth hormone?

YES: Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathway.

What IGF 1 inhibits?

The hypothalamic growth hormone (GH)-releasing hormone (GHRH) promotes non-rapid eye movement sleep (NREMS). Insulin-like growth factor-1 (IGF-1) acts as a negative feedback in the somatotropic axis inhibiting GHRH and stimulating somatostatin.

Is IGF 1 detectable in a urine test?

There is no widely available urine test for IGF-1, but like human growth hormone, IGF-1 can be detected in blood tests.

Does whey protein have IGF 1?

Whey protein stimulates fasting insulin and casein stimulates circulating IGF-1. Both milk protein fractions seem to be important, but different, in the growth-stimulating effect of milk.

Does Testosterone increase IGF 1?

It is hypothesized that testosterone might induce the synthesis of IGF-1 which could affect cell proliferation.

What is a IGF 1 blood test?

A somatomedin C test, also called an insulin-like growth factor-1 (or IGF-1) test, helps doctors evaluate whether a person is producing a normal amount of human growth hormone (hGH, or somatotropin).

IGF-1 LR3 dosage

In scientific and clinical studies doses of IGF-1 LR3 are mentioned as 20-100 mcg per day.

Overview

IGF-1 LR3 is prolonged version of endogenous peptide hormone IGF-1 (human insulin-like growth factor 1). It is strong agonist of the IGF-1 receptor, but with very low affinity for the insulin-like growth factor-binding proteins (IGFBPs) unlike regular IGF-1. As a result, it is approximately three times more potent than regular IGF-1. IGF-1 LR3 can be suitable treatment in catabolic states and diseases (such as muscular dystrophy). Because has a strong ability to maintain and build muscle. The production of more IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells.