DES(1-3) IGF-1 description
Protein DES(1-3) IGF-1 is a truncated version of peptide hormone IGF-1 (insulin-like growth factor 1) in which the tripeptide Gly-Pro-Glu is absent from the N-terminus end of the protein. In other words, DES(1-3) IGF-1 lacks the first 3 amino acids at the N-terminus of insulin-like growth factor 1, and consists from total of 67 amino acids, relative to the 70 amino acids of IGF-1.
It is naturally occurring endogenous hormone in human and mammals, that has been found in the human brain, cow colostrum, and pig uterine tissue. The amino acid sequence of DES(1-3) IGF-1 is TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA.
Clinical trials and DES(1-3) IGF-1 results
Scientific research and clinical trials have shown, that DES(1-3) IGF-1 binds with high-affinity to IGF-1 receptor. And thanks to its a much reduced binding to IGF-binding proteins, caused by the absence of the glutamate at position 3 (tripeptide Gly-Pro-Glu at the N-terminus) is even 10-fold more potent than regular IGF-1 in stimulating hypertrophy and proliferation of cells!
Clinical opportunities for DES(1-3) IGF-1 have not yet been very evaluated, but could apply in catabolic states (using the peptide to induce anabolism in catabolic conditions such as muscular dystrophy) as well as for the treatment of inflammatory bowel diseases. IGF-1 has a strong ability to maintain and build muscle, especially DES(1-3) IGF-1 form. In addition to a direct anabolic effect on skeletal muscle, the production of more IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells (satellite cells) – real growth of new muscle cells, and IGF-1 is the only hormone that can do this. DES(1-3) IGF-1 is also promising candidate for treat of a number of neurological diseases.
Scientifically investigated possible benefits of DES(1-3) IGF-1
- Overall regeneration of the whole body (incl. internal organs), increased cellular repair
- Anti-aging effects, rejuvenation and the ability to slow-down the aging
- Increased collagen production, healthier skin, helping to smooth out wrinkles
- Strong anabolic effect / promoting muscle growth, strength and performance
- Ability to induce muscle hyperplasia – the growth of new muscle cells
- Strong anti-catabolic effect / protection against muscle wasting
- Increased bone mineral content / greater bone mineral density
- Improved cognitive functions, improves learning and memory
- Promotes regeneration of the nervous system and brain health
- May reduce risk of heart & cardio-vascular diseases
- Strengthened immune system
- Anti-inflammatory effects
- Improved gut health
DES(1-3) IGF-1 possible side-effects
- Possible correlation insulin-like growth factor 1 to certain forms of cancer development (however, performed studies are often unclear, and often with conflicting or very different results)
- Risk for diabetes (performed studies are often unclear)
- Low blood sugar
- Joint pain
DES(1-3) IGF-1 FAQ
Does IGF-1 build muscle?
YES: IGF-1 has a strong ability to promote muscle growth, especially DES(1-3) IGF-1 form. In addition to a direct anabolic effect on skeletal muscle, the production of more IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells (satellite cells) – real growth of new muscle cells (IGF-1 is the only hormone that can do this). Due from this properties it is very promising candidate for treat catabolic diseases such as muscular dystrophy etc.
How does IGF-1 affect insulin?
YES: Insulin-like growth factor 1 (IGF-1) and growth hormone (GH) interact with insulin to modulate its control of carbohydrate metabolism. New studies shows that blocking the effect of GH in the presence of low serum IGF-1 concentrations enhances insulin sensitivity.
What is a normal IGF-1 level?
One study reports the median serum IGF-I level is about 370 ng/ml at the age of 18. The European Prospective Investigation into Cancer and Nutrition (EPIC) study reported an average serum IGF-1 level of 200-210 ng/ml, suggesting that this is a typical level for adults on a Western diet. Low IGF-1 levels associated with an increased risk of disease or mortality are generally about 70-80 ng/ml or lower.
Can IGF-1 cause diabetes?
UNCLEAR: Studies showed that low and high IGF-I levels are related to impaired glucose tolerance and to a higher risk of type 2 diabetes.
Does IGF 1 cause water retention?
MAY: IGF-I treatment may cause fluid and sodium retention.
Does organic milk have IGF 1?
YES: All milk based products, whether they’re non organic dairy products or organic milk and organic cheese, contain a certain amount of IGF-1.
Why is it called Insulin Like Growth Factor?
The name insulin-like growth factor reflects the fact that these substances have insulin-like actions in some tissues, though they are far less potent than insulin in decreasing blood glucose concentrations.
Does insulin affect growth hormone?
YES: Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathway.
What IGF 1 inhibits?
The hypothalamic growth hormone (GH)-releasing hormone (GHRH) promotes non-rapid eye movement sleep (NREMS). Insulin-like growth factor-1 (IGF-1) acts as a negative feedback in the somatotropic axis inhibiting GHRH and stimulating somatostatin.
Is IGF 1 detectable in a urine test?
There is no widely available urine test for IGF-1, but like human growth hormone, IGF-1 can be detected in blood tests.
Does whey protein have IGF 1?
Whey protein stimulates fasting insulin and casein stimulates circulating IGF-1. Both milk protein fractions seem to be important, but different, in the growth-stimulating effect of milk.
Can IGF 1 be absorbed orally?
Despite the common assumption that IGF-I cannot be significantly absorbed when taken orally.
Does Testosterone increase IGF 1?
It is hypothesized that testosterone might induce the synthesis of IGF-1 which could affect cell proliferation.
What is a IGF 1 blood test?
A somatomedin C test, also called an insulin-like growth factor-1 (or IGF-1) test, helps doctors evaluate whether a person is producing a normal amount of human growth hormone (hGH, or somatotropin).
How do you reconstitute IGF-1?
Reconstitute lyophilized recombinant human IGF-1 in sterile, distilled water to a concentration of 0.1-1.0 mg/ml
DES(1-3) IGF-1 dosage
In scientific and clinical studies doses of DES (1-3) IGF-1 are reported as 50-150 mcg per day, intramuscularly, directly into muscle where an anabolic effect is required. And regarding the duration of treatment with DES (1-3) IGF-1, periods of from 4 to 12 weeks are reported.
DES(1-3) IGF-1 is a truncated version of peptide hormone IGF-1 (insulin-like growth factor 1). DES(1-3) IGF-1 binds with high-affinity to IGF-1 receptor and thanks to its a much reduced binding to IGF-binding proteins, is 10-fold more potent than regular IGF-1. It is promising candidate mainly for treat catabolic states as muscular dystrophy and neurological diseases.